C2-SYMMETRIC PYRROLIDINE-BASED CHIRAL AMMONIUM SALTS AS A PHASE-TRANSFER CATALYST

摘要

Chiral pyrrolidinium salts having substituents at the a, a' positions were synthesized to develop a chiral phase-transfer catalyst which have more simplified structure. The catalytic function of these synthesized catalysts was evaluated using asymmetric benzylation of N-(diphenylmethylene)glycine tert-butyl ester, and α,α'-disubstituded pyrrolidinium salts having an alkyl chain with a hydroxyl group at a chiral center were found to afford moderate enantioselectivity.