DEVELOPMENT AND APPLICATIONS OF AN OXAZOLE-FORMING REACTION

摘要

We review an oxazole-forming reaction devised in our laboratory. The technique allows the facile assembly of 2,5-disubstituted-4-carbalkoxy oxazoles, including 5-amino and 5-alkenyl oxazoles. Applications of this chemistry in the total synthesis of muscoride A, siphonazoles, and other oxazole alkaloids are described.