MODIFICATION OF D-RING MOIETY OF STEROIDS - A NOVEL PALLADIUM CATALYZED BAEYER-VILLIGER TYPE REARRANGEMENT OF CYCLIC SILYLENOL ETHER DERIVATIVES

摘要

A novel Baeyer-Villiger type rearrangement reaction of cyclic silylenol ether derived from dehydroepiandrosterone via oxygen and catalytic amount of palladium acetate in the presence of DMSO has been developed. The reaction proceeded at low temperature and high pressure of oxygen to afford corresponding α,β-unsaturated lactones in moderate yields.