SECOND GENERATION PALLADIUM-CATALYZED CYCLO-ALKENYLATION IN IRIDOID LACTONE SYNTHESIS: TOTAL SYNTHESES OF (±)-ONIKULACTONE AND (±)-MITSUGASHIWALACTONE

摘要

Type-II iridoid lactones, onikulactone (1) and mitsugashiwalactone (2), were synthesized by employing the second generation palladium-catalyzed cycloalkenylation reaction as the key step.