STEREOSELECTIVE INTRAMOLECULAR CYCLIZATION OF ISOPENTENYL BENZAMIDE VIA π-ALLYLPALLADIUM COMPLEX CATALYZED BY Pd(0)

摘要

An efficient procedure was developed to synthesize oxazoline as key intermediate in the total synthesis of (+)-lactacystin using palladium(0)-catalyzed intramolecular cyclization of isopentenyl benzamide via a π-allylpalladium complex. A convenient and efficient method was developed for the synthesis of the optically pure α-amino-β-hydroxy acid.