REGIOSELECTIVITY IN DIRECT ARYLATION OF BENZANILIDE POSSESSING OXYGEN SUBSTITUENT IN THE BENZOYL PART USING PALLADIUM WITHOUT PHOSPHINE LIGAND

摘要

The direct arylation of benzanilide (1) possessing ether oxygen(s) in benzoyl part was examined under phosphine ligand-free conditions, which afforded ortho-product (2) and para-product (3) in very similar ratio to presence of P(o-Tol)3 conditions. This results suggest that bulkiness of palladium under phosphine-free conditions would be comparable to that of P(o-Tol)3 conditions.