NOVEL APPLICATION OF ELECTROOXIDATIVE METHOD FOR THE CYCLIZATION OF N-BENZYL-2-(HYDROXYMETHYL)- AND N-BENZYL-2-(2-HYDROXYETHYL)PIPERH)INES

摘要

Several novel 1,3-oxazinane and oxazolidine derivatives were obtained from the corresponding N-benzyl-2-(2-hydroxyethyl)- and N-benzyl-2-(hydroxymethyl)piperidines via electrochemical oxidation. The reactions were carried out in methanol under basic conditions. The yields of the cyclic products were significantly improved using catalytic amounts of iodide ions, which presumably act as effective electron carriers in the two-electron oxidation process.