SYNTHESES AND EVALUATION AS GLYCOSIDASE INHIBITOR OF 1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL ANALOGS OF SALACINOL, A POTENT α-GLUCOSIDASE INHIBITOR ISOLATED FROM AYURVEDIC MEDICINE, SALACIA RETICULATA

摘要

N-Alkylated deoxynojirimycin (10) bearing the same alkyl chain as salacinol (1), a potent oc-glucosidase inhibitor isolated from Ayurvedic traditional medicine, Salacia reticulata, was found to inhibit both rat intestinal maltase and sucrase as strong as 1, while 10 has been reported to be inactive against glucoamylase G2 from Aspergillus niger. Its O-desulfate (12) was also found active against these enzymes, and characteristic sulfate anion moiety of 1 was found not essential for the oc-glucosidase inhibitory activity.