PTERIDINES CXX. SYNTHESIS AND PROPERTIES OF TETRAHYDRO- PTERINS COUPLED TO 1,4-DIHYDROPYRIDINES

摘要

N~2-Isobutyroyl-5,6,7,8-tetrahydropterins (6-10) have been coupled with nicotinic acid to form the N~5-nicotinoyl derivatives 11-15. Quaternization at the pyridine moiety led to 19-31 which can be reduced to the corresponding N-substituted 1,4-dihydropyridine dertivatives 35-39. Partial deacylation of the isobutyroyl group afforded the various types of terahydropterins 16-18, 32-34 and 40-42. The newly synthesized 5,6,7,8-tetrahydropterin derivatives have been characterized by pK_a-determinations, UV- and NMR-spectra as well as elemental analyses.