FIRST SYNTHESIS OF RACEMIC CONCENTRICOLIDE, AN ANTI-HIV-1 AGENT ISOLATED FROM THE FUNGUS DALDINIA CONCENTRICA

摘要

Concentricolide, a novel compound with anti-HIV-1 activity and isolated from ascomycete Daldinia concentrica, has been synthesised for the first time as a racemate from furan-3-carbaldehyde and dihydrofuran-2(3H)-one via a Diels-Alder reaction. The identity of the synthetic sample was verified by comparison of its spectral data with those of an authentic sample.