LIVER X RECEPTOR (LXR) MODULATORS WITH DIBENZ[b,f]-[1,4]OXAZEPIN-11-ONE, (Z)-DIBENZ[b,f]AZOCIN-6-ONE, AND 11,12-DIHYDRODIBENZ[b,f]AZOCIN-6-ONE SKELETONS

Atsushi Aoyama; Hiroshi Aoyama; Makoto Makishima

首页> 外文期刊>Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry >LIVER X RECEPTOR (LXR) MODULATORS WITH DIBENZ[b,f]-[1,4]OXAZEPIN-11-ONE, (Z)-DIBENZ[b,f]AZOCIN-6-ONE, AND 11,12-DIHYDRODIBENZ[b,f]AZOCIN-6-ONE SKELETONS

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LIVER X RECEPTOR (LXR) MODULATORS WITH DIBENZ[b,f]-[1,4]OXAZEPIN-11-ONE, (Z)-DIBENZ[b,f]AZOCIN-6-ONE, AND 11,12-DIHYDRODIBENZ[b,f]AZOCIN-6-ONE SKELETONS

机译：具有DIBENZ [b，f]-[1,4] OXAZEPIN-11-ONE，（Z）-DIBENZ [b，f] AZOCIN-6-one和11,12-DHYDRODIBENZ [b]的LIVER X受体（LXR）调节器，f] AZOCIN-6-ONE骨架

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Conformationally restricted heterocyclic analogs of carba-T0901317 with dibenz[b,f][1,4]oxazepin-11-one, 11,12-dihydrodibenz[b,f]azocin-6-one, and (Z)-dibenz[b,f]-azocin-6-one skeletons were prepared as candidate for liver X receptor (LXR) agonists. In vitro transactivation assay revealed that the activity depends on the nature of the linking group.

机译：具有dibenz [b，f] [1,4] oxazepin-11-one，11,12-dihydrodibenz [b，f] azocin-6-one和（Z）-dibenz [b]的carba-T0901317的构象受限杂环类似物，f]-偶氮霉素-6-一骨架被制备为肝X受体（LXR）激动剂的候选者。体外反式激活测定表明活性取决于连接基团的性质。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2009年第9期|共8页
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Atsushi Aoyama; Hiroshi Aoyama; Makoto Makishima;
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1. LIVER X RECEPTOR (LXR) MODULATORS WITH DIBENZ[b,f]-[1,4]OXAZEPIN-11-ONE, (Z)-DIBENZ[b,f]AZOCIN-6-ONE, AND 11,12-DIHYDRODIBENZ[b,f]AZOCIN-6-ONE SKELETONS [J] . Atsushi Aoyama, Hiroshi Aoyama, Makoto Makishima Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2009,第9期

机译：具有DIBENZ [b，f]-[1,4] OXAZEPIN-11-ONE，（Z）-DIBENZ [b，f] AZOCIN-6-one和11,12-DHYDRODIBENZ [b]的LIVER X受体（LXR）调节器，f] AZOCIN-6-ONE骨架
2. Molecular Modeling Studies on 11H-Dibenz[b,e]azepine and Dibenz[b,f][1,4]oxazepine Derivatives as Potent Agonists of the Human TRPA1 Receptor [J] . Molecules . 2010,第12期

机译：作为人类TRPA1受体强效激动剂的11H-二苯并[b，e]氮杂和二苯并[b，f] [1,4]氧杂氮衍生物的分子建模研究
3. Dopamine/Serotonin receptor ligands VI. Dibenz[g,f]-1-oxa-4-Azacycloundecene and Dibenz[d,g]-12-azacycloundecene: Synthesis of two new heterocyclic ring systems as potential ligand for dopamine receptor subtypes [J] . Thomas W.Wittig, Christoph Enzensperger, Jochen Lehmann Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2003,第4期

机译：多巴胺/ 5-羟色胺受体配体VI。 Dibenz [g，f] -1-oxa-4-氮杂环十一碳烯和Dibenz [d，g] -12-氮杂环十一碳烯：合成两个新的杂环系统作为多巴胺受体亚型的潜在配体
4. Change of ATP binding cassette transporter A1 and liver X receptor α expression in diabetic minipig skeletal muscle Change of LXRα/ABCA1 pathway in diabetic skeletal muscle [C] . Shi-Lin Tang, Yin Kai, Zhong-Cheng Mo, 2011 International Conference on Remote Sensing, Environment and Transportation Engineering . 2011

机译：糖尿病迷你猪骨骼肌中ATP结合盒转运蛋白A1和肝X受体α表达的变化糖尿病骨骼肌LXRα/ ABCA1途径的变化
5. Development of lentiviral vector mediated gene delivery techniques and stable cell lines for investigating the action of ethanol and other allosteric modulators of glycine and GABAA receptors. [D] . Modi, Dimple Ashok. 2011

机译：慢病毒载体介导的基因传递技术和稳定细胞系的开发，用于研究乙醇和甘氨酸和GABAA受体的其他变构调节剂的作用。
6. The Liver X Receptor Is Upregulated in Monocyte-Derived Macrophages and Modulates Inflammatory Cytokines Based on LXRα Polymorphism [O] . Hyoun-Ah Kim, Wook-Young Baek, Mi-Hwa Han, 2019

机译：肝X受体在单核细胞衍生的巨噬细胞中上调并基于LXRα多态性调节炎症性细胞因子。
7. Molecular Modeling Studies on 11H-Dibenz[b,e]azepine and Dibenz[b,f][1,4]oxazepine Derivatives as Potent Agonists of the Human TRPA1 Receptor [O] . Qiang Sun, Ping-Hua Sun, Fa-Jun Song, 2010

机译：11H-Dibenz [b，e]氮杂卓和Dibenz [b，f] [1,4]氧氮杂衍生物作为人TRpa1受体的强效激动剂的分子模拟研究
8. Dibenz(b,f)(1,4)Oxazepine:Colorimetric and UV-Spectrophotometric Estimation of Trace Quantities. [R] . martin,john j. morton, linwood b. 1976

机译：Dibenz（b，f）（1,4）Oxazepine：比色法和紫外分光光度法测定痕量。

LIVER X RECEPTOR (LXR) MODULATORS WITH DIBENZ[b,f]-[1,4]OXAZEPIN-11-ONE, (Z)-DIBENZ[b,f]AZOCIN-6-ONE, AND 11,12-DIHYDRODIBENZ[b,f]AZOCIN-6-ONE SKELETONS

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