Samarium(II) Iodide-Mediated Intramolecular Aldol-Type Cyclization

摘要

The #alpha#-substituted #alpha#,#beta#-epoxy ketone having a formyl group in the molecule reacted with samarium(II) iodide to afford cyclized spiro ketones formed by an intramolecular aldol-type reaction. However, in the presence of proton source the ratio of spiro products decreased and the yield of hydrindanone increased. The #alpha#-substituted #alpha#, #beta#-unsaturated cyclopentenone derivative smoothly cyclized into the same hydrindanone.