Simple Synthesis of 1,3,4,5a,6,10b,11,11a-Octahydro-2H-Pyrazino[1',2':1,5]Pyrrolo[2,3-b]Indole Derivatives Based on 1-Hydroxyindole Chemistry

摘要

3-Substituted (3S,6S)-6-(1-hydroxyindol-3-ylmethyl)-2,5-piperazine-diones are prepared for the first time. They are shown to be suitable intermediates for the synthesis of 3,10b-disubstituted (3S,5aR, 10bS, 11aS)-1,3,4,5a,6,10b, 11, 11a-octahydro-2H-pyrazino[1'2':1,5]pyrrolo[2,3-b]indole-1,4-dione derivatives.