MANNICH REACTION OF 5-HYDROXY-beta-CARBOLINE.APPLICATION TO THE SYNTHESIS OF NOVEL OXAZINOPYRIMIDOCARBOLINE DERIVATIVES

摘要

5-Hydroxy-beta-carboline 4 was synthesized and submitted to the Mannich reaction towards formaldehyde and some primary amines.It undergoes an original reaction of bis-aminomethylation-cyclisation giving the oxazinopyrimidocarboline.derivatives 5a-d.The structure of these compounds was confirmed by their high-resolution mass,IR,~1H NMR and ~(13)C NMR spectral data.