OXIDATIVE CONVERSION OF FUNCTIONALIZED 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES TO THE CORRESPONDING PYRIMIDIN-2(1H)-ONES USING ACTIVATED CARBON—MOLECULAR OXYGEN SYSTEM

摘要

Efficient synthesis of functionalized pyrimidin-2(1H)-ones was achieved by oxidation of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) using activated carbon—molecular oxygen (O2) system. Various DHPMs were easily prepared by Biginelli reactions starting from aldehydes, β-ketoesters and urea. Therefore, the present method provides general and versatile protocol for the synthesis of a variety of functionalized pyrimidin-2(1H)-ones.