DEUTERIUM INCORPORATION INTO RESERPINE

摘要

Treatment of reserpine (1) with TFA-d under various conditions demonstrated that deuterium incorporation proceeds much more slowly than the epimerization.Indirect evidence was thereby obtained for the mechanism of the acid-catalysed epimerization of reserpine (1) that proceeds through C-3-N_b bond cleavage.Furthermore,the effectiveness of TFA as an epimerization reagent was demonstrated.