FACILE ONE-POT SYNTHESIS OF FUNCTIONALIZED ACETYLENES FROM ARYL AND HETEROARYL ALDEHYDES USING LITHIUM TRIMETHYLSILYLDIAZOMETHANE

摘要

The reaction of aryl and heteroaryl aldehydes with lithium trimethylsilyldiazomethane followed by treatment with n-BuLi and then electrophiles in one-pot efficiently afforded functionalized acetylenes.Functionalized acetylenes are well-known to be useful building blocks in organic synthesis.