SYNTHESIS OF CRIBROSTATIN 6 AND ITS RELATED COMPOUNDS

摘要

The synthesis of cribrostatin 6 (1),which shows good biological activity as a dark blue cancer cells growth inhibitor and a number of pathogenic bacteria and fungi,was achieved in two steps from 1-acetylaminomethyl-5,7-diethoxy-8-hydroxy-6-methylisoquinoline (14).The related compounds (8 approx 11) were also synthesized,and the antimicrobial activities of 1 and its nine related compounds (5 approx 13) were investigated.