A CONVENIENT SYNTHESIS OF FLUORINE-CONTAINING DIHYDROBENZO[b][1,4]DIAZEPINOLS AND ITS APPLICATION TO A SYNTHESIS OF NOVEL N-SULFINYLANILINES

摘要

The reactions of 1,1,1,5,5,5-hexafluoro-3-(isobutoxymethylene)-pentane-2,4-dione(1)with various benzene-1,2-diamines gave 2,5-dihydro-3-trifluoroacetyl-2-trifluoromethyl-1H-benzo[b][1,4]diazepines(5)in moderate to high yields under very mild conditions.Also,2,5-dihydro-3-perhaloalkanoyl-2-perhaloalkyl-1H-benzo[b][1,4]diazepines(7)were synthesized successfully by quite similar manner.Reactions of thus obtained dihydrobenzo[b][1,4]-diazepinols(5)with thionyl chloride gave unexpected novel fluorine-containing N-sulfmylanilines(9).