A CONCISE APPROACH TO(±)-TUBIFOLINE BASED ON THE PALLADIUM-CATALYZED CROSS-COUPLING REACTION OF INDOLYLBORATE

摘要

The palladium-catalyzed tandem cyclization-cross-coupling protocol using 1H-indol-2-yltrialkylborate(indolylborate)proved to be a versatile approach to the generation of 2-(4-piperidylmethyl)indole,which was successfully used for the preparation of(±)-tubifoline.