SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME NEW PYRIMIDINE DERIVATIVES

摘要

The utility of ethyl 6-methyl-2-oxo-4-phenyl-1,2-dihydropyrimidine-5-carboxylate (1) in the synthesis of some new pyrido[1,2-f]pyrimidine, pyrazolo-[3,4-b]pyrido[1,2-f[pyrirnidine, 6-(4-substituted styryl)pyrimidine, pyrido[4,3-d]-pyrimidine, pyrimido[5,4-d]pyridazine and substituted-6-(thien-2-yl)pyrimidine derivatives is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out.