CONVENIENT SYNTHESIS OF 1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONES BY IODOCYCLIZATION OF t-BUTYL 2-VINYLPHENYLCARBAMATES

摘要

It has been found that t-butyl 2-vinylphenylcarbamate derivatives underwent iodocyclization on treatment with iodine in the presence of sodium hydrogencarbonate to afford 4-iodomethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one derivatives in generally good yields.The reduction of these 4-iodomethyl derivatives with tributyltin hydride gave the corresponding 4-methyl derivatives in good yields.