SYSNTHESIS OF 3-0-ACYLATED EPICATECHIN DERIVATIVES VIA SEQUENTIAL ONE-POT MULTI-STEP REACTIONS

摘要

An effective approach for the synthesis of epicatechin derivatives based on sequential one-pot multi-step reactions is described.Reductive etherification of the disulfanyl derivative was promoted with a catalytic amount of TfOH,providing the cis-substituted benzopyran derivative in a stereoselective manner.