SYNTHEIS OF UNUSUAL TRICYCLIC RING SYSTEMS OF BIOLOGICAL INTEREST

摘要

We describe a new synthesis of tricyclic scaffolds that incorporate a fusion of triazole with 1,4-benzodiazepine utilizing intramolecular "click" chemistry.Heterocyclic chemistry has always been one of the most invaluable sources of novel compounds with diverse biological activity,many heterocycles exhibit unique ability in a wide array of functions such as mimicking the structure of peptides and binding reversibly to proteins.