CELL GROWTH AND CELL CYCLE INHIBITORY ACTIVITIES OF 20-EPIDIOSGENYL SAPONIN FROM CALAMUS INSIGNIS

Takashi Ohtsuki; Noriko Kaneko; Takashi Koyano

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CELL GROWTH AND CELL CYCLE INHIBITORY ACTIVITIES OF 20-EPIDIOSGENYL SAPONIN FROM CALAMUS INSIGNIS

机译：CAL蒲中20-表鬼臼酰基皂苷的细胞生长和细胞周期抑制活性

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A new 20 epi-diosgenyl saponin (1) was isolated from the stems of Calamus insignis (Palmae) by bioassay guided purification.The chemical structure of 1 was established on the basis of spectroscopic analysis and chemical means.Compound 1 showed cell growth inhibitory activity against HeLa cells (IC50;5.1 mu M) and exhibited a cell cycle inhibitory effect at the G2/M stage at the concentration of 2.9 mu M by flow cytometric analysis.

机译：通过生物测定指导纯化从of蒲茎中分离出新的20个表二恶臭基皂苷（1），在光谱分析和化学手段的基础上建立了1的化学结构，化合物1具有抑制细胞生长的活性通过流式细胞术分析，它对HeLa细胞（IC50; 5.1μM）具有抑制作用，并在G2 / M阶段以2.9μM的浓度显示出对细胞周期的抑制作用。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry 》 |2007年第0期| 共6页
作者
Takashi Ohtsuki; Noriko Kaneko; Takashi Koyano;
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正文语种 eng
中图分类杂环化合物 ;
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1. CELL GROWTH AND CELL CYCLE INHIBITORY ACTIVITIES OF 20-EPIDIOSGENYL SAPONIN FROM CALAMUS INSIGNIS [J] . Takashi Ohtsuki, Noriko Kaneko, Takashi Koyano Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2007 ,第0期

机译：CAL蒲中20-表鬼臼酰基皂苷的细胞生长和细胞周期抑制活性
2. New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death [J] . QueirozM.-J.R.P., PeixotoD., CalhelhaR.C., European Journal of Medicinal Chemistry: Chimie Therapeutique . 2013 ,第Null期

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3. Growth Inhibitory Activity of Honokiol through Cell-cycle Arrest, Apoptosis and Suppression of Akt/mTOR Signaling in Human Hepatocellular Carcinoma Cells [J] . Ji-Young Hong, Hyen Joo Park, KiHwan Bae, Natural product sciences . 2013 ,第2期

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4. Synthesis of compounds with specific growth inhibitory activityagainst acute T lymphoblastic leukemia cells [C] . Yuki Fujita, Chihiro Yoshida, Yoshifumi Hachiro 日本化学会春季年会 . 2020

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5. Consumption Pattern of Calamus Tenuis Roxb. Shoots of The Forest Village Natives of Dibrugarh, Assam and Investigation of Its Cytotoxicity Activity on Cancer and Normal Cells (A549, MCF7 and L132) [D] . Thakur, Pawan Kumar . 2016

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7. Study on cell cycle inhibitory component of Calamus insignis etc. [O] . 大槻崇, Ohtsuki Takashi 100

机译：菖蒲（Calamus insignis）等细胞周期抑制成分的研究

CELL GROWTH AND CELL CYCLE INHIBITORY ACTIVITIES OF 20-EPIDIOSGENYL SAPONIN FROM CALAMUS INSIGNIS

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