A SYNTHESIS OF (+-)-DIHYDRONITRARAINE

摘要

A short synthesisi of (+-)-dihydronitraraine(1)from an unknown 5,6,7,8-tetrahydroisoquinoline ester(3)is presented.The Fry reaction of tetrahydroisoquinolinium salt(4),followed by cyclization and hydrogenation,gave an alloyohimbane derivative (6),which was reduced to yield dihydronitraraine(1).Complete ~1H NMR and ~(13)C NMR data of dihydronitraraine (1)and intermediate(6)and intermediate(6)are reported.