REACTION OF 3-ETHOXYCARBONYLINDOLIZINE-1，2-DICAR-BOXYLIC ANHYDRIDE WITH （3-BROMO-4-PYRIDYL）-TRIISOPROPOXYTITANIUM：SYNTHESIS OF 5，12-DIMETHYL-INDOLIZINO[2,1-g]ISOQUINOLINE (ELLIPTICINE ANALOGUE)

摘要

Reaction of indolizine-1,2-dicarboxylic anhydride with (3-bromo-4-pyridyl)triisopropoxytitanium gave 2-(3-bromoisonicotinoyl)-3-ethoxycarbonyl-indolizine-1-carboxylic acid as the sole product.The indolizine-1-carboxylic acid could be converted to 5,12-dimethylindolizine[2,1-g]isoquinoline in six steps.