HIGHLY DIASTEREOSELECTIVE REDUCTION OF #gamma#-BUTYROLACTONES WITH CONTIGUOUS CHIRAL CENTERS

摘要

Diasteroselective reduction of #gamma#-keto amides,which were easily prepared by the reaction of a zinc homoenolate of butanamide with acid chlorides in the presence of Pd(0) catalyst,was achieved.Cyclization of the rocucts,#gamma#-hydroxy amides,under various conditions gave #alpha#,#beta#-disubstituted and #alpha#,#beta#,#gamma#-trisubstituted #gamma#-butyrolatones with high diastereoisomeric putities.