Organopalladium complex containing 5-amino-3#-l,3,4-thiadiazolin-2-ones as metalloreceptor for dna/rna nucleobases

摘要

Macrocycles containing two 5-amino-3H-l,3,4-thiadiazolin-2-ones linking the 3-and 5-positions of the heterocycle unit and one 1,3-benzenedimethanethiol were prepared via the regiospecific N-alkylation of 5-amino-3H-l,3,4-thiadiazolin-2-one.The 1,3-benzenedimethanethiol sites chelated to palladium metal ion to give an organopalladium metalloreceptor.The structures of the macrocycle and metalloreceptor were established using ~1H and ~(13)C NMR,IR,and MS spectrometry.The molecular recognition of the metalloreceptor(5)was examined for some DNA/RNA nucleobases using 1H NMR spectrometry.The complexation ability increased in the order uracil/thymine < adenine < cytosine/imidazole.