Synthesis of N-Trifluoroacetyl-2-Hydroxynoraporphine By Radical Reaction Of P-Quinol Acetate Of N-Trifluoro-Acetyl-L-(2-Iodoveratryl)Methyl-L,2,3,4-Tetrahydro-7-Methoxyisoquinolin-6-Ol

摘要

Radical reaction of p-quinol acetate (8b) of N-trifluroroacetyl-1-(2-iodoveratryl)methyl-l,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ol (7b) using tributyltin hydride gave the corresponding noraporphine (9)(45 %),while that of the bromo congener (8a) failed. Similar reaction of 8b using tris(trimethylsilyl)silane improved the yield (75 %) of 9.