Ent-Kaurane Diterpenoids form Isodon Rubescens var. Lushiensis

摘要

Three new 6,7-seco-6,19:6,20-diepoxy-1alpha, 7-olide-ent-kaurane diterpenoids, ludongnins C-E (1-3), along with six known analogs, macrocalyxoformins A (4) and B (5), sculponeatins A (6) and B(7), and ludongnins A (8) and B (9), were isolated from Isodon rubescens var. lushiensis. The structures of the new compounds were determined on the basis of the spectroscopic evidences. Compound (5) exhibited significant inhibitory activities against the Bcap37 and K562 cell lines with IC_50 = 0.82 and 0.62 mug/mL, respectively.