A convenient route to the soluble guanylate cyclase activator YC-1 and its N2 regioisomer

Patricia A.Fernandez; Tom Bellamy; Marcel Kling; David J.Madge; David L.Selwood

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A convenient route to the soluble guanylate cyclase activator YC-1 and its N2 regioisomer

机译：可溶性鸟苷酸环化酶激活剂YC-1及其N2区域异构体的便捷途径

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A new route to the soluble guanylate cyclase (sGC) activator YC-1 and its N2 regioisomer has been established with a Mitsunobu mediated N-alkylation as the key step. The route is utilised in the synthesis of a potential photoaffinity label.

机译：以Mitsunobu介导的N-烷基化为关键步骤，已经建立了一条通往可溶性鸟苷酸环化酶（sGC）活化剂YC-1及其N2区域异构体的新途径。该途径用于潜在的光亲和标记的合成。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry 》 |2001年第9期| 共4页
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Patricia A.Fernandez; Tom Bellamy; Marcel Kling; David J.Madge; David L.Selwood;
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1. A convenient route to the soluble guanylate cyclase activator YC-1 and its N2 regioisomer [J] . Patricia A.Fernandez, Tom Bellamy, Marcel Kling, Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2001 ,第9期

机译：可溶性鸟苷酸环化酶激活剂YC-1及其N2区域异构体的便捷途径
2. Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide [J] . Stone JR., Marletta MA. Chemistry & biology . 1998 ,第5期

机译：YC-1和一氧化碳协同激活可溶性鸟苷酸环化酶：一氧化氮激活过程中对铁-组氨酸键裂解作用的影响
3. Soluble Guanylate Cyclase Is Activated Differently by Excess NO and by YC-1: Resonance Raman Spectroscopic Evidence [J] . Mohammed Ibrahim Emily R. Derbyshire Alexandra V. Soldatova Michael A. Marletta and Thomas G. Spiro Biochemistry . 2010 ,第23期

机译：过量的NO和YC-1分别激活可溶性鸟苷酸环化酶：共振拉曼光谱证据
4. DEVELOPMENT OF A NOVEL BIOLUMINESCENT ASSAY FOR NITRIC OXIDE BY USING SOLUBLE GUANYLATE CYCLASE [C] . YOSHIHIRO SANO, MASAYUKI SEKI, SHIGEYA SUZUKI, The 15th International Symposium on Bioluminescence and Chemilminescence(第十五届生物发光和化学发光国际会议)论文集 . 2008

机译：可溶性胍盐环化酶法开发一种新型的生物发光法检测一氧化氮
5. I. The synthesis of YC-1 analogues for a photoaffinity study of soluble guanylate cyclase. II. Synthesis of kifunensine and analogues as inhibitors of endoplasmic reticulum alpha mannosidase I. [D] . Hering, Kirk William. 2004

机译：I.YC-1类似物的合成，用于可溶性鸟苷酸环化酶的光亲和性研究。二。 Kifunensine及其类似物作为内质网α甘露糖苷酶I抑制剂的合成。
6. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. [O] . C. C. Wu, F. N. Ko, S. C. Kuo, 1995

机译：YC-1通过不依赖NO的可溶性鸟苷酸环化酶激活来抑制人血小板聚集。
7. Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives [O] . I.S. Severina, N.V. Pyatakova, A.Yu. Shchegolev, 2015

机译：YC-1，No-供体和Yc-1在1,2,3-三唑基-1,2,5-恶二唑衍生物的无依赖性活化中的溶解性胍基环酶激活的增强性和Yc-1的不依赖性活化的增长

A convenient route to the soluble guanylate cyclase activator YC-1 and its N2 regioisomer

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