Asymmetric Pauson-Khand Reactions of Chiral Sulfinamines: Asymmetric Synthesis of 3-Azabicyclo[3.3.0]OCT-5-EN-7-one Derivatives

摘要

Unprecedented asymmetric Pauson-Khand reactions of chiral sulfinamides are described. Cobalt-catalyzed reactions of chiral N-allyl-N-propargyl-N-arylsulfinamide derivatives were carried out in dichloromethane at - 20 deg C approx room temperature under carbon monoxide atmosphere in the presence of Co_2(CO)_8 to give chiral 3-azabicyclo[3.3.0]oct-5-en-7-one with moderate or low enantisoelectivity.