THE PREPARATION AND CHARACTERIZATION OF NINETEEN NEW PHTHALIDYL SPIROHYDANTOINS

摘要

Nineteen new N,N'-disubstituted phthalidyl spirohydantoins (6a-s) were prepared for the purpose of pharmacological testing.Their structure was deduced from the IR,1H-NMR,13C-NMR,mass spectra and elemental analysis.The two possible structural isomers - only one of which is formed - can be distinguished unequivocally on the basis of selective diastereotopicity of the a-methylene hydrogens adjacent to N-3' of the hydantoin ring.