DESIGN AND SYNTHESIS OF NOVEL RING-EXPANDED ARBEKACIN ANALOGUES

Nobuto Minowa; Yukiko Hiraiwa; Yoshihisa Akiyama

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DESIGN AND SYNTHESIS OF NOVEL RING-EXPANDED ARBEKACIN ANALOGUES

机译：新型环扩阿贝卡那类似物的设计与合成

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Novel homologated aminoglycosides having a seven-membered ring were designed and synthesized by treatment of 5-keto arbekacin with diazomethane in CH2Cl2-Et2O.The ring-expanded arbekacin analogue showed good antibacterial activity against Staphylococcus aureus and Escherichia coli including aminoglycoside-resistant bacterial strain.

机译：通过重氮甲烷在CH2Cl2-Et2O中对5-酮基阿贝卡星进行处理，设计合成了具有七元环的同系氨基糖苷类化合物。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2007年第8期|共7页
作者
Nobuto Minowa; Yukiko Hiraiwa; Yoshihisa Akiyama;
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正文语种 eng
中图分类杂环化合物;
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1. DESIGN AND SYNTHESIS OF NOVEL RING-EXPANDED ARBEKACIN ANALOGUES [J] . Nobuto Minowa, Yukiko Hiraiwa, Yoshihisa Akiyama Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2007,第8期

机译：新型环扩阿贝卡那类似物的设计与合成
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DESIGN AND SYNTHESIS OF NOVEL RING-EXPANDED ARBEKACIN ANALOGUES

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