AN EFFICIENT,ONE-POT SYNTHESIS OF FOSFOMYCIN DIALKYL ESTERS FROM (R)-2-TOSYLOXYPROPANAL

摘要

(R)-2-Tosyloxypropanal (4) was prepared from D-mannitol in a 7-step sequence (51% overall yield).Addition of dialkyl phosphonates to 4 in the presence of titanium isopropoxide and the subsequent treatment with DBU stereoselectively afforded,in one-pot,fosfomycin dimethyl (5a) and dibenzyl (5b) esters both in 58% isolated yield.