PRACTICAL APPROACH FOR HYDROHETEROARYLATION OF ALKYNES USING BENCH-STABLE CATALYST

摘要

A simple and convenient method for hydroheteroarylation of alkynes using air-stable catalyst precursors is described.The addition of a solution of AlMe3 in hexane to Ni(acac)2 and tri(cyclopentyl)phosphonium tetrafluoroborate([Cyp3PH]BF4)rapidly generates an active Ni(0)/Cyp3P catalyst for cis-hydroheteroarylation of alkynes under mild conditions.The catalytic reaction is applicable to a wide range of heteroarenes to give heteroaryl-substituted ethenes in excellent stereo-and regioselectivities.