ONIUM SALT SUPPORTED ORGANIC SYNTHESIS IN WATER:APPLICATION TO UGI'S 4-COMPONENTS REACTION

摘要

The utilization of the Onium Salt Supported Organic Synthesis methodology for Ugi's 4 components reaction in water is presented.An easy preparation of substrates followed by quantitative reactions led to peptidic moieties which are subsequently easily isolated in good yields and purities.Advantages of the OSSOS strategy including extreme simplification of purification and monitoring of the reaction are presented.