Synthesis and characterizationof potential photoabelineg probes for studying the antiviral mechanisms of eicar

摘要

The designed photolabeling probes:5-diazonium-1-beta-D-ribofurano-syl-1H-imidazole-4-carboxamide(1) and 5-azido -1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamid e(2) were synthesized via a short and convenient synthetic route,namely by diazotizing AICAR and subseuently prforming substitution with NaN_3.Although 1 was not stable even at low temperatures,2 showed a rapid and clean photochemcial reactions,which suggests that it may be a valuable tool for use in photolabeling studies.