Direct conversion of 2-acetamido-2-deoxysugars sto 1,2-oxazoline derivatives by dehydrative cyzlization in water

摘要

Sugar oxazoline derivatives were directly prepared by dehydrative eyclization of 2-acetamido-2-deoxysugars using a water-soluble earbodiimide in water.N-Acetyl-D-glucosamine,N-acetyl-D-galaetosamine,and N,N'-diacetylchitobiose were converted to the corresponding 1,2-oxazoline derivatives in 37,28,and 40%yields,respectively.