Preparation and derivatization of the core compound of macrosphelide E-G series

摘要

The macrosphelide core (2) possessing a skeleton of macrosphelide E-G series was newly prepared,and its oxidative derivatization was investigated.The compound (2) was found to be less reactive to oxidations compared to the epimeric core (1),and it was suggested that there is a considerable difference among their geometry-optimized conformations,which affected the reactivity.