Asymmetric intramolecular aza-michael reaction using environmentally friendly organocatalysis

摘要

This communication describes enantioselective intramolecular aza-Michael reaction to prepare 1,2,3,4-tetrahydroisoquinolines by using organocatalysts. The organocatalytic reaction offers new green chemical process in heterocyclic chemistry. Additional noting, both enantiomers of the product were easily synthesized by using two types of organocatalysts prepared from the same amino acid.