A total synthesis of a new type of furo[3,2-h]Isoquinoline alkaloid,TMC-120B

Teppei Kumemura; Tominari Choshi; Aki Hirata; Mitsuko Sera; Yohhei Takahashi; Junko Nobuhiro; Satoshi Hibino

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A total synthesis of a new type of furo[3,2-h]Isoquinoline alkaloid,TMC-120B

机译：新型呋喃[3,2-h]异喹啉生物碱TMC-120B的全合成

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A total synthesis of a new furo[3,2-h]isoquinoline alkaloid,TMC-120B (2) has been completed in sixteen steps.The key step is the synthesis of 7,8-disubstituted isoquinoline (17) based on the thermal electrocyclic reaction of 1-azahexatriene system involving the benzene 1,2-bond.

机译：新的呋喃[3,2-h]异喹啉生物碱TMC-120B（2）的全部合成已通过十六个步骤完成。关键步骤是在热的基础上合成7,8-二取代异喹啉（17）。 1-氮杂己三烯系统的电环反应涉及苯1,2-键。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2003年第1期|共5页
作者
Teppei Kumemura; Tominari Choshi; Aki Hirata; Mitsuko Sera; Yohhei Takahashi; Junko Nobuhiro; Satoshi Hibino;
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正文语种 eng
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1. A total synthesis of a new type of furo[3,2-H]isoquinoline alkaloid, TMC-120B [J] . Teppei Kumemura, Tominari Choshi, Aki Hirata, Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2003,第0期

机译：新型呋喃[3,2-H]异喹啉生物碱TMC-120B的全合成
2. IMPROVED SYNTHESIS OF THE NEW FURO[3,2-h]ISOQUINOLINE ALKALOIDS TMC-120B AND TMC-120A, AND THEIR INHIBITORY ACTIVITIES AGAINST IFN-γ AND IL-4 PRODUCTION [J] . Tominari Choshi, Teppei Kumemura, Haruto Fujioka Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2012,第1期

机译：新型呋喃并[3,2-h]异喹啉碱TMC-120B和TMC-120A的合成及其对IFN-γ和IL-4产生的抑制活性
3. Synthesis of the new furo[3,2-h]isoquinoline alkaloid, TMC-120B from Aspergillus ustus [J] . Kumemura T, Choshi T, Hirata A, Chemical and Pharmaceutical Bulletin . 2005,第4期

机译：利用uspergillus ustus合成新的呋喃并[3,2-h]异喹啉生物碱TMC-120B
4. Unified Total Synthesis of Stemoamide-type Alkaloids Featuring Chemoselective Assembly of Five-membered Building Blocks [C] . Makoto Yoritate, Yoshito Takahashi, Hayato Tajima 日本化学会春季年会講演予稿集 . 2018

机译：统一的总合成溶于五元建筑块的化学选择性组装。
5. Intramolecular Cope-Type Hydroamination of Alkenes in the Synthesis of Alkaloids: Total Synthesis of (+/-)-Coniine and (+/-)-Desbromoarborescidine A and Studies on a Novel Amination Strategy Towards Manzamine A. [D] . Dion, Isabelle. 2012

机译：生物碱合成中烯烃的分子内Cope型加氢胺化：（+/-）-丝氨酸和（+/-）-去溴基硼烷甲酰胺A的全合成以及对Manzamine A的新型胺化策略的研究。
6. Aminomethylation/hydrogenolysis as an alternative to direct methylation of metalated isoquinolines – a novel total synthesis of the alkaloid 7-hydroxy-6-methoxy-1-methylisoquinoline [O] . Benedikt C Melzer, Jan G Felber, Franz Bracher 2018

机译：氨基甲基化/氢解法可替代金属化异喹啉的直接甲基化–生物碱7-羟基-6-甲氧基-1-甲基异喹啉的新型合成方法
7. First total synthesis of ampullosine, a unique isoquinoline alkaloid isolated from Sepedonium ampullosporum, and of the related permethylampullosine [O] . Didier F. Vargas, Enrique L. Larghi, Teodoro S. Kaufman 2019

机译：第一次完全合成Ampullosine，一种独特的异喹啉生物碱从衍生吡腔中分离的独特的异喹啉生物碱，以及相关的渗透吡咯胺

A total synthesis of a new type of furo[3,2-h]Isoquinoline alkaloid,TMC-120B

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