Structural and conformational studies of 3-(6-chloropyridazin-3-yl)-N,N-dimethylpiperazinium iodide and 3-(6-chloropyridazin-3-yl)-N,N-dimethyl-homopiperazinium iodide with central nicotinic action

摘要

The structural characteristics of 3-(6-chloropyridazin-3-yl)-N,N-dimethyl-homopiperazinium iodide (3c) and 3-(6-chloropyridazin-3-yl)-N,N-dimethyl-homopiperazinium iodide (4c) have been investigated in order to understand their actions at the nAchR receptor.The results of the X-Ray molecular structures and of the conformational analysis have been compared with the structure of epibatidine that represents one of the most potent nicotinic agonist.