Synthesis of substituted pyrroles from N-vinylic phosphazenes derived from beta-amino acids and alpha-bromo ketones

摘要

Synthesis of di-, tri- and tetrasubstituted pyrroles by reaction of N-vinylic phosphazenes derived from beta-amino acids with alpha-bromo ketones is described. Pyrroles~1 are very important compounds, not only because they occur in a large number of natural products, but also because they are constituents of neutral pigements, enzymes and biologically active compounds of interest to medicinal chemistry.~2