EFFICIENT CONSTRUCTIONS OF THE FOUR DIFFERENT THIENOPYRIMIDINONE SKELETONS VIA VARIOUS CYCLOCONDENSATION OF o-AMINOTHIENONITRILE WITH CARBONYL COMPOUNDS

摘要

A series of new thienopyrimidinone derivatives were synthesized via a novel, straightforward and efficient tandem cyclo condensation of o-aminothienonitrile 1 and carbonyl compounds 2 in different conditions. The synthesized four thienopyrimidinone skeletons were thieno[2,3-d]pyrimidinone 3, tert-hydroxythieno[2,3-d]pyrimidinone 4, symmetrical tetracycle thienothiophene-pyrimidone 5 and thienopyrimidine 6 respectively. Their plausible mechanisms were proposed. The properties of compound 5 were investigated.