CATALYTIC CYCLIZATION OF 2,3-DIBROMOPROPIONATES WITH BENZYL AZIDES TO AFFORD 1-BENZYL-1,2,3-TRIAZOLE-4-CARBOXYLATE: THE USE OF A NONTOXIC BISMUTH CATALYST

摘要

We synthesized 1,2,3-triazoles via the cyclization of 2,3-dibromopropionates with benzyl azides. Bismuth chloride is an efficient catalyst, and the reaction is accelerated by weak bases such as sodium acetate. A variety of functional groups are compatible with this catalytic protocol, and it takes advantage of oxygen stable catalyst and substrates because the reactive dibromides are saturated.