Benzyloxymethyl Group as a Convertible Internal Ligand for La(OTf)_3-Catalyzed 7-endo Ring-Opening of Hydroxy Epoxide

摘要

The benzyloxymethyl group at C5 of cis-5,6-epoxyheptanol promoted 7-endo selective ring-opening of the hydroxy epoxide under La(OTf)_3-catalyzed conditions to give r-2-methyl-c-3-benzyloxymethyl-t-3-hyroxyoxepane, whose benzyloxymethyl group was transformable to a methyl group.