Total Synthesis of Plagiochins A and D, Macrocyclic Bis(Bibenzyls), By Pd(O) Catalyzed Intramolecular Stille-Kelly Reaction

Yoshiyasu Fukuyama; Hideyuki Yaso; Takashi Mori; Hironobu Takahashi; Hiroyuki Minami; Mitsuaki Kodama

首页> 外文期刊>Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry >Total Synthesis of Plagiochins A and D, Macrocyclic Bis(Bibenzyls), By Pd(O) Catalyzed Intramolecular Stille-Kelly Reaction

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Total Synthesis of Plagiochins A and D, Macrocyclic Bis(Bibenzyls), By Pd(O) Catalyzed Intramolecular Stille-Kelly Reaction

机译：Pd（O）催化的分子内Stille-Kelly反应完全合成Plagiochins A和D，大环双（联苄）

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Total syntheses of plagiochins A (1) and D (4), the former of which exhibits a signficant neurotrophic activity, have been accomplished. The key 16-membered ring closure in 4has been achieved directly from the dibromoperrottein derivative (7) by Pd(O) catalyzed intramolecular Stille-Kelly reaction, whereas 1 has been synthesized from the dibromide (28) via the trimethylstannyl compounds (29) and (30) by Pdz(O) catalyzed intramolecular Stille reaction.

机译：已经完成了斜柏碱A（1）和D（4）的总合成，前者表现出明显的神经营养活性。通过Pd（O）催化的分子内Stille-Kelly反应直接从二溴过膜蛋白衍生物（7）实现了4中的关键16元环闭合，而1则是由二溴化物（28）通过三甲基锡烷基化合物（29）和（30）由Pdz（O）催化的分子内Stille反应。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry 》 |2001年第1期| 共16页
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Yoshiyasu Fukuyama; Hideyuki Yaso; Takashi Mori; Hironobu Takahashi; Hiroyuki Minami; Mitsuaki Kodama;
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1. Total Synthesis of Plagiochins A and D, Macrocyclic Bis(Bibenzyls), By Pd(O) Catalyzed Intramolecular Stille-Kelly Reaction [J] . Yoshiyasu Fukuyama, Hideyuki Yaso, Takashi Mori, Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2001 ,第1期

机译：Pd（O）催化的分子内Stille-Kelly反应完全合成Plagiochins A和D，大环双（联苄）
2. Effect of plagiochin E, an antifungal macrocyclic bis(bibenzyl), on cell wall chitin synthesis in Candida albicans [J] . Xiu-zhen WU, Ai-xia CHENG, Ling-mei SUN, 中国药理学报：英文版 . 2008 ,第012期

机译：抗真菌大环双（联苄）plagiochin E对白色念珠菌细胞壁几丁质合成的影响
3. Total synthesis of plagiochin D by an intramolecular SNAr reaction [J] . Cortes Morales J.C., Guillen Torres A., González-Zamora E. European journal of organic chemistry . 2011 ,第17期

机译：通过分子内SNAr反应全合成斜柏青D
4. Solvent-Controlled Cascade Reaction of Ugl/Pd-Catalyzed Intramolecular Divergent C-H Fumctionalization for Regies elective Synthesis of Cyclopropanated N-Heterocycles [C] . Tianyi Shang, Yan Pan, Zhong Chen International Conference on Advanced Composite Materials and Manufacturing Engineering . 2020

机译：UGL / PD催化的溶剂控制级联反应UGL / PD催化分子内发散的C-H富脉冲率的调节选择性合成环丙烷的N-杂环
5. 1. Axially-chiral 7-membered N-heterocyclic carbenes: Synthesis and application to palladium-catalyzed intramolecular aerobic oxidation of olefins 2. Development of palladium-catalyzed aerobic oxidative olefin amination reactions [D] . Scarborough, Christopher C. 2008

机译：1.轴向手性7元N-杂环卡宾：烯烃的钯催化分子内需氧氧化的合成及应用2.钯催化需氧氧化烯烃胺化反应的发展
6. Enantioselective Total Synthesis of Cannogenol-3-O-α-L-Rhamnoside via Sequential Cu(II)-Catalyzed Michael Addition/Intramolecular Aldol Cyclization Reactions [O] . Bijay Bhattarai, Pavel Nagorny -1

机译：通过顺序的Cu（II）催化的迈克尔加成/分子内羟醛环化反应对映体选择性合成Cannogenol-3-O-α-L-鼠李糖苷
7. Effect of plagiochin E, an antifungal macrocyclic bis(bibenzyl), on cell wall chitin synthesis in Candida albicans [O] . Xiu-zhen Wu, Ai-xia Cheng, Ling-mei Sun, 2008

机译：抗真菌大氯联苯甲基苄蛋白e，抗真菌大氯联苯（丁苄基），在Candida albicans中的细胞壁脑蛋白质合成的影响
8. Phase Transfer Pd(O) Catalyzed Polymerization Reactions. 1. Synthesis of 1,2-(4,4'-Dialkoxyaryl)Acetylene Monomers and 1,4-Bis(2-(4',4''-Dialkoxyphenyl)Ethynyl)Benzene Derivatives by Phase Transfer Pd(O)/Cu(I) Catalyzed Coupling Reactions. [R] . Pugh, C., Percec, V. 1990

机译：相转移pd（O）催化的聚合反应。 1.相转移pd（O）/ Cu合成1,2-（4,4'-二烷氧基芳基）乙炔单体和1,4-双（2-（4'，4'-二烷氧基苯基）乙炔基）苯衍生物（I）催化的偶联反应。

Total Synthesis of Plagiochins A and D, Macrocyclic Bis(Bibenzyls), By Pd(O) Catalyzed Intramolecular Stille-Kelly Reaction

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