A new cyclic triterpene saponin, phyteujaposide (1) and eight known compounds (2-9) were isolated from the leaves of Phyteuma japonicum. The structure of the new compound (1) was elucidated by ID and 2D data analysis, acid hydrolysis and GC-MS. Compounds 7 and 9 potently inhibited the NO production in LPS-activated BV-2 cells and compounds 5 and 6 showed a significant secretion induction of NGF in C6 glioma without cell toxicity.
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