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A NEW CYCLIC TRITERPENE SAPONIN FROM PHYTEUMA JAPONICUM

机译:番茄植株的一种新的环三萜皂苷。

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摘要

A new cyclic triterpene saponin, phyteujaposide (1) and eight known compounds (2-9) were isolated from the leaves of Phyteuma japonicum. The structure of the new compound (1) was elucidated by ID and 2D data analysis, acid hydrolysis and GC-MS. Compounds 7 and 9 potently inhibited the NO production in LPS-activated BV-2 cells and compounds 5 and 6 showed a significant secretion induction of NGF in C6 glioma without cell toxicity.
机译:从日本疫霉菌的叶子中分离出一种新的环状三萜皂苷,植物苦参皂甙(1)和八个已知化合物(2-9)。通过ID和2D数据分析,酸水解和GC-MS阐明了新化合物(1)的结构。化合物7和9有效抑制LPS激活的BV-2细胞中NO的产生,化合物5和6在C6胶质瘤中显示出NGF的显着分泌诱导作用,而没有细胞毒性。

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